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北京时间2023年11月3日晚八点，iCANX Talks第168期邀请到墨西哥蒙特雷理工学院的Grissel Trujillo-de Santiago进行分享！更多精彩，敬请期待！

【嘉宾介绍】

Grissel Trujillo-de Santiago

Tecnologico de Monterrey

Chaotic bioprinting: Biofabrication of microstructured multi-material tissues using chaotic flows

【Abstract】

Packaged layered microstructures abound in mammalian tissues and provide them with key biological functionalities. Biofabricating these complex architectures is challenging using current technologies. In this talk, we will present advances in chaotic bioprinting, an extrusive printing technique that uses deterministic chaotic advection to fabricate constructs with complex multilayered and multimaterial architectures at an unprecedented level of resolution and throughput. We will showcase its use to bioprint muscle-like tissues that mimic the aligned hierarchical architecture of native skeletal muscle, and prevascularized tissues. Furthermore, we will discuss how the method can be easily adapted to biofabricate constructs with architectural transitions (axially and radially) within the very same piece or structure, without the existence of joints or assemblies, as it occurs in natural tissues.

哺乳动物组织中存在大量的包装层状微结构，它们具有关键的生物功能。利用现有技术对这些复杂结构进行生物制造具有挑战性。本讲座将介绍混沌生物打印技术的进展。这是一种挤出式打印技术，利用确定性混沌平流，以前所未有的分辨率和吞吐量制造具有复杂多层和多材料结构的构建体。Grissel Trujillo-de Santiago将展示该技术在模仿原生骨骼肌排列分层结构的类肌肉组织和血管前组织生物打印中的应用。此外，还将讨论如何将该方法轻松地应用于生物制造，在同一块材料或结构中实现结构转换（轴向和径向），而无需像天然组织那样存在关节或装配。

【BIOGRAPHY】

Grissel Trujillo-de Santiago is an Assistant Professor at Tecnológico de Monterrey and CSO of FORMA Foods. Grissel’s research is focused on the development of technologies based in chaos to produce multilayered and multimaterial 3D micro-structured living tissues. She was trained as a Chemistry & Pharmacy Biologist at Universidad Autónoma de Nuevo León (summa cum laude); she obtained her MSc degree in Biotechnology (summa cum laude), and her PhD degree in Biotechnology from Tecnológico de Monterrey. Dr. Trujillo de Santiago conducted research in Material Sciences at the Università degli Studi di Napoli Federico II (Naples, Italy) during her PhD program. She was a Postdoctoral Research Fellow at Dr. Khademhosseini’s Lab in the Harvard-MIT Health Sciences and Technology Division (2014-2016) and the Microsystems Technology Laboratories at MIT. Dr. Trujillo is member of the National System of Researchers in Mexico (level 2). She has a Mexican patent and 6 patent-pending technologies, including 3D-chaotic-printing. Grissel has 70+ publications (4800+ citations, H-index of 26). She has graduated 5 Ph.D., and 14 M.Sc students. Grissel is an associate editor at ACS Materials Letters and a scientific advisor for the United Nations University-LATAM. Grissel has received several awards, including the Young Researchers Prize from the Mexican Academy of Sciences, the Fellowship for Women in Science from L’Oréal-UNESCO, the Rómulo-Garza award in the category of research that led to entrepreneurship from Xignux and Tecnológico de Monterrey, the award to the innovation in Bionanotechnology from CINVESTAV and Neolpharma, was named “Distinguished Citizen” by her hometown, Matamoros Coahuila, and is member of the “Distinguished Circle of Faculty Members” of the School of Engineering and Sciences at Tecnológico de Monterrey.

Grissel Trujillo-de Santiago是蒙特雷理工大学的助理教授，也是FORMA食品公司的首席运营官。Grissel的研究重点是开发基于混沌的技术，以生产多层次、多材料的三维微结构活组织。她曾在新莱昂州自治大学（Universidad Autónoma de Nuevo León）接受明升手机与药剂生物学家培训（最优等成绩），并在蒙特雷理工大学获得生物技术硕士学位（最优等成绩）和生物技术博士学位。在攻读博士学位期间，Trujillo de Santiago 博士在那不勒斯费德里科第二大学（意大利那不勒斯）从事材料明升体育app研究。她曾在哈佛-麻省理工学院健康明升体育app与技术部哈德莫塞尼博士实验室（2014-2016年）和麻省理工学院微系统技术实验室担任博士后研究员。特鲁希略博士是墨西哥国家研究人员系统（二级）成员。她拥有一项墨西哥专利和6项正在申请的专利技术，包括3D混沌打印技术。格里塞尔发表了70多篇论文（被引用 4800多次，H 指数为26）。她已培养出5名博士生和14名硕士生。格里塞尔是ACS Materials Letters的副编辑，也是联合国大学拉塔姆分校的明升体育app顾问。Grissel曾多次获奖，其中包括墨西哥明升体育app院青年研究员奖、欧莱雅-教科文组织女性明升体育app奖学金、Rómulo-Garza研究成果创业奖、ACS Materials Letters（美国明升手机学会材料快报）副主编奖、ACS Materials Letters（美国明升手机学会材料快报）副主编奖、ACS Materials Letters（美国明升手机学会材料快报）副主编奖。