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论文题目：Integrating rare genetic variants into pharmacogenetic drug response predictions

期刊：

作者：Takakazu Oka et al.

发表时间：2017/3/3

数字识别码：10.1186/s13030-017-0090-z

原文链接：

以往的随机对照试验表明，坐姿等长瑜伽可以缓解慢性疲劳综合征/肌痛性脑脊髓炎（CFS / ME）患者的疲劳感。然而，一些患者长时间坐着或练习坐姿等长瑜伽很困难。目前，尚无针对严重症状患者的治疗性干预措施。

在BMC期刊BioPsychoSocial Medicine发表的文章Development of a recumbent isometric yoga program for patients with severe chronic fatigue syndrome/myalgic encephalomyelitis: A pilot study to assess feasibility and efficacy 中显示，研究者开发了一种卧姿等长瑜伽项目，大约需要20分钟来完成，旨在缓解重度CFS / ME患者的疲劳感。这项初步研究旨在评估该项目的可行性、安全性和实用性。

这项初步研究共纳入12例CFS / ME成人患者。其中6例患者由于严重疲劳而不愿意练习坐姿等长瑜伽（第1组），另外6例患者曾练习过坐姿等长瑜伽（第2组）。在3个月内，两组患者平均每2~4周在瑜伽教练的指导下练习一次卧姿等长瑜伽，其他时间也可在家中练习。在瑜伽教练最后一次指导练习之前和之后使用心境状态量表（POMS）问卷来评估等长瑜伽对疲劳的短期影响。在整个干预期前后使用Chalder疲劳量表（FS）问卷评估等长瑜伽对疲劳的长期影响。同时还记录了受试者的不良反应、对项目的满意度以及对瑜伽姿势（坐姿或卧姿）的偏好。

所有受试者均完成了全部干预。在两组中，练习20分钟瑜伽后POMS疲劳评分显著下降，并且在3个月干预期后Chalder FS评分也显著下降。未出现严重不良反应。相比坐姿等长瑜伽，第2组中的所有受试者均更倾向于卧姿等长瑜伽。

这项研究结果表明，卧姿等长瑜伽对于CFS / ME患者而言是一种可行且可接受的治疗方法，即使是对于练习坐姿等长瑜伽时遇到困难的患者也是如此。

摘要：

Background

Our previous randomized controlled trial demonstrated that isometric yoga in a sitting position reduces fatigue in patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). However, some patients experience difficulties sitting or practicing isometric yoga in a sitting position for long periods. To date, therapeutic interventions for patients with severe symptoms have not been established. Therefore, we developed a recumbent isometric yoga program, which takes approximately 20 min to complete, designed to reduce fatigue in patients with severe CFS/ME. The aim of this pilot study was to assess the feasibility, safety, and usefulness of this program.

Methods

This pilot study included 12 adult patients with CFS/ME. Six patients were reluctant to practice isometric yoga in a sitting position because of the severity of their fatigue (group 1). The remaining six patients had previously practiced isometric yoga in a sitting position (group 2). For 3 months, the patients of both groups practiced recumbent isometric yoga every 2 to 4 weeks with a yoga instructor and at home on other days if they could. The short-term effects of isometric yoga on fatigue were assessed using the Profile of Mood Status (POMS) questionnaire immediately before and after their final session with the yoga instructor. The long-term effects of isometric yoga on fatigue were assessed using the Chalder Fatigue Scale (FS) questionnaire before and after the intervention period. Adverse events, satisfaction with the program, and preference of yoga position (sitting or recumbent) were also recorded.

Results

All subjects completed the intervention. In both groups, the POMS fatigue score was significantly decreased after practicing the 20-min yoga program and the Chalder FS score was decreased significantly after the 3-month intervention period. There were no serious adverse events. All subjects in group 2 preferred the recumbent isometric yoga program over a sitting yoga program.

Conclusions

This study suggests that recumbent isometric yoga is a feasible and acceptable treatment for patients with CFS/ME, even for patients who experience difficulty practicing isometric yoga in the sitting position.

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期刊介绍： is the official journal of the Japanese Society of Psychosomatic Medicine. It publishes peer-reviewed research that encompasses all aspects of the interrelationships between the biological, psychological, social, and behavioral factors of health and illness.

2017 Journal Metrics

Citation Impact

1.00 - 2-year Impact Factor

n/a - 5-year Impact Factor

0.669 - Source Normalized Impact per Paper (SNIP)